Personal information
Name : Zhi-hui Feng
Day of birth : Dec, 1983
E-mail: hugofzhe@gmail.com
zhfeng@mail.xjtu.edu.cn
Employment
2012 – Present
Center for Mitochondrial Biology and Medicine, Frontier Institute of Science and Technology (FIST), Xi’an Jiaotong University, China
2009 – Present
Director’s Assistant, Institute of Mitochondrial Biology and Medicine, Xi’an Jiaotong University, China
Education
2006 –2011 Ph.D Insititute for nutritional sciences, Shanghai insitutes for biological Sciences, Chinese Academy of Sciences, Shanghai, China
Superviser : Dr. Yan Chen ; Dr. Jiankang Liu
2008- 2011 Visiting student Institute of Mitochondrial Miology and Medicine, Xi’an Jiaotong University, Xi’an, China
2009 Visiting student Department of Urology, Chao Family Cancer Center, UC Irvine Medicial Center, USA
2001 - 2005 BS Marine College, Shandong University, Weihai, China.
Activities
2011 Organizing committee, International Symposium of Mitochondrial Biology and Medicine & Chinese-Mit’2011.
2011 Organizing committee, Nestlé Research Center-Xi’an Jiaotong University Nutrition and Health Laboratory Opening Ceremony.
2008 - 2009 Establishment of Institute of Mitochondrial biology and Medicine (IMBM), Xi’an, China
Honors
2011 Outstanding student Nestlé prize, Nestlé Research Center and Xi’an Jiaotong University Joint Laboratory
2011 Oxygen Club of California Young Investigator Prize, International Symposium on Mitochondrial Biology and Medicine
2010 Excellent student awards, Institute of mitochondrial biology and medicine, Xi’an Jiaotong University
2004 Shandong University excellent student awards
2003 Shandong University excellent student awards
2001 Shandong University excellent student awards
Research experience
1. Mitochondrial targeting of nutrtional intervention on age related macular degeneration (AMD). Degeneration of retinal pigment epithelium (RPE) cell is considered major cause that induces AMD, while oxidative stress induced mitochondrial dysfunction is closely related RPE degeneration. Using ARPE-19 cell model, I have selected several nutritients that prevent oxidative stress induced RPE cell death by activating mitochondrial biogenesis, improving mitochondrial function and inducing phase II enzymes.
2. Mitochondrial dynamic regulation in obesity, diabetic development and effects of nutrional intervention. Mitochondrial dysfunction is associated with development of obesity and diabetes. I’m interested in finding out how mitochondrial dynamic including mitochondrial biogenesis, degradation, fusion, fission affect mitochondrial function during obesity and diabetic progression. Using several cell and animal models, I intent to find effective nutritients which could inhibit obesity, diabetes, and associated fatty liver development by regulating mitochondrial function.
3. Involvement of mitochondrial dysfunction in prenatal stress induced offspring congivitive decline and effects of nutritional intervention. It has been well indicated that prenatal stress could induce offspring cognitive decline. My study showed that prenatal stress induced mitochondrial dysfunction and oxidative damage in offspring hippocampus might be the major cause. Besides the well-know role in children brain development, I found novel role of docosahexaenoic acid (22 :6n-3 ; DHA) in protecting prenatal stress induced cognitive dysfuntion involving the modulation of mitochondrial functions and dynamics.
4. Autophagy and mitochondrial remodeling in long-term strenuous exercise. Physical exercise is considered to exert a positive effect on health. While, I found strenuous or excessive exercise causes fatigue and damage to muscle and immune functions thereby decrease endurance capacity. I’m interested in cross talking between autophay and mitochonrial dynamic during exercise.
Research Profile (http://www.researcherid.com/rid/E-7408-2011 or https://scholar.google.com/citations?user=W0uShLwAAAAJ&hl=en)
Representive Publications (*corresponding author)
Research ID: E-7408-2011
1. Zheng A, Li H, Cao K, Xu J, Zou X, Li Y, Chen C, Liu J*, Feng Z*. Maternal hydroxytyrosol administration improves neurogenesis and cognitive function in prenatally stressed offspring. J Nutr Biochem. 2014 Nov 12. pii: S0955-2863(14)00224-1. doi: 10.1016/j.jnutbio.2014.10.006.
2. Cao K, Zheng A, Xu J, Li H, Liu J, Peng Y, Long J, Zou X, Li Y, Chen C, Liu J*, Feng Z*. AMPK activation prevents prenatal stress-induced cognitive impairment: modulation of mitochondrial content and oxidative stress. Free Radic Biol Med. 2014 Oct;75:156-66.
3. Chen C, Han X, Zou X, Li Y, Yang L, Cao K, Xu J, Long J, Liu J*, Feng Z*.
4-methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid (C75), an inhibitor of fatty-acid synthase, suppresses the mitochondrial fatty acid synthesis pathway and impairs mitochondrial function. J Biol Chem. 2014 Jun 13;289(24):17184-94.
4. Xu J, Cao K, Li Y, Zou X, Chen C, Szeto IM, Dong Z, Zhao Y, Shi Y, Wang J, Liu J*, Feng Z*. Bitter gourd inhibits the development of obesity-associated fatty liver in C57BL/6 mice fed a high-fat diet. J Nutr. 2014 Apr;144(4):475-83.
5. Zou X, Yan C, Shi Y, Cao K, Xu J, Wang X, Chen C, Luo C, Li Y, Gao J, Pang W, Zhao J, Zhao F, Li H, Zheng A, Sun W, Long J, Szeto IM, Zhao Y, Dong Z, Zhang P, Wang J, Lu W, Zhang Y, Liu J*, Feng Z*. Mitochondrial dysfunction in obesity-associated nonalcoholic fatty liver disease: the protective effects of pomegranate with its active component punicalagin. Antioxid Redox Signal. 2014 Oct 10;21(11):1557-70.
6. Cao K, Xu J, Zou X, Li Y, Chen C, Zheng A, Li H, Li H, Szeto IM, Shi Y, Long J, Liu J*, Feng Z*.Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice. Free Radic Biol Med. 2014 Feb;67:396-407.
7. Feng Z, Zou X, Jia H, Li X, Zhu Z, Liu X, Bucheli P, Ballevre O, Hou Y, Zhang W, Wang J, Chen Y, Liu J. Maternal docosahexaenoic acid feeding protects against impairment of learning and memory and oxidative stress in prenatally stressed rats: possible role of neuronal mitochondria metabolism. Antioxid Redox Signal. 2012 Feb 1;16(3):275-89.
8. Feng Z, Bai L, Yan J, Li Y, Shen W, Wang Y, Wertz K, Weber P, Zhang Y, Chen Y, Liu J. Mitochondrial dynamic remodeling in strenuous exercise-induced muscle and mitochondrial dysfunction: regulatory effects of hydroxytyrosol. Free Radic Biol Med. 2011 May 15;50(10):1437-46.
9. Feng Z, Liu Z, Li X, Jia H, Sun L, Tian C, Jia L, Liu J. α-Tocopherol is an effective Phase II enzyme inducer: protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells. J Nutr Biochem. 2010 Dec;21(12):1222-31.
