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邵永平
来源: | 作者: | 发布时间:2013-04-15 | 浏览:9109次

 

Dr. Yongping Shao (邵永平)

Laboratory of resistance to targeted cancer therapy
email:
yongpings[at]gmail.com


Education
9/2001-5/2007
    Ph.D in Molecular Biology, State University of New York at Albany
9/1997-6/2000    M.S. in Botany,  Fudan University
9/1993-6/1997    BS in Biology, Fudan University

Employment
7 /2013 -
                 Group Leader I , Center for Translational Medicine , Frontier Institute of Science and  Technology (FIST), Xi’an Jiaotong University, China
12/ 2008-5/2013   Postdoctoral Fellow, Kimmel Cancer Center, Thomas Jefferson University
5/2007-11/ 2008   Postdoctoral Associate, State University of New York at Albany

Award
2011
  Jefferson Postdoctoral Research Symposium Poster Presentation Award
2011  Jefferson Collage of Graduate Study Postdoctoral Travel Fellowship
2010  “Outrun the Sun” National Melanoma Research Scholar Award
2007  Distinguished Doctoral Dissertation Award, SUNY Albany             
2004  “Dr. Peter Marfey” Book Scholarship, SUNY Albany

Research Interest

1. Mechanisms of Resistance to targeted therapy in human melanoma.
2. Development of small peptide inhibitors that target the RAS/RAF/MEK/ERK pathway.
3. Development of antibody-based drug delivery methods.


Publications

1. Hartsough E, Shao Y, Aplin A.E. 2014. Resistance to RAF Inhibitors Revisited. J Invest Dermatol. 134:319-25.

2. Shao Y. and Aplin A.E. 2012. BH3-only protein silencing contributes to acquired resistance to PLX4720 in human melanoma. Cell Death Differ. 19:2029-39.

3. Shao Y. and Aplin A.E. 2012. ERK-regulated phosphorylation of serine 77 regulates Bmf pro-apoptotic activity. Cell Death Dis. 3(1):e253.

4. Aplin A.E., Kaplan F. and Shao Y. 2011.  Mechanisms of resistance to B-RAF inhibitors in melanoma. J Invest Dermatol. 131(9):1817-20.

5. Kaplan F. M., Shao Y., Mayberry M.M., Aplin A.E. 2011.  Hyperactivation of MEK-ERK1/2 signaling and resistance to apoptosis induced by the oncogenic B-RAF inhibitor, PLX4720, in mutant N-RAS melanoma cells. Oncogene. 30(3):366-71

6. Shao Y. and Aplin A.E.  2010.  Akt3-mediated resistance to apoptosis in B-RAF-targeted melanoma cells. Cancer Res. 15; 70(16):6670-81.

7. Shao Y. and Wang I.N. 2009. Effect of late promoter activity on bacteriophage lambda fitness. Genetics. 181(4):1467-75.

8. Shao Y. and Wang I.N. 2008. Bacteriophage adsorption rate and optimum lysis time. Genetics. 180(1):471-82.

9. Shao Y., Feldman-Cohen L.S. and Osuna R. 2008. Biochemical identification of base and phosphate contacts between Fis and a high affinity DNA binding site. J Mol Biol. 380(2):327-39.

10.Shao Y., Feldman-Cohen L.S. and Osuna R. 2008. Functional characterization of the Escherichia coli Fis-DNA binding sequence. J Mol Biol. 376(3):771-85.

 

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